Dosierung: repeating the activated clotting time can demonstrate restored coagulation (1). Unerwünschte Wirkungen: cardiopulmonary side effects from protamine administration are similar to intravenous vitamin K, and include hypotension, anaphylaxis and pulmonary hypertension. These side effects most frequently occur when infusing the protamine bolus too rapidly; the maximum rate should be 50 mg over 10 min (1). Referenzen: |