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bleeding risk

Epidemiology:
  • Prevalence: the rates of major bleeding (with and without bridging therapy) are 2.7% among patients with a mechanical heart valve, 2% amoug those with atrial fibrillation, and 1.9% among those with venous thromboembolism.
Procedures: low risk means <1.5% bleeding, high risk means >1.5% bleeding, or in vulnerable areas.
  • Anesthesiology:
    • low risk:
      • endotracheal intubation
      • peripheral catheter placement, nontunneled catheter (peripherally inserted central catheter) placement
    • high risk: spinal and epidural anesthesia (potential for profound neurologic consequences)
  • Cardiac surgery:
    • low risk: none
    • high risk: all
  • Cardiovascular:
    • low risk: diagnostic coronary angiography (controversial)
    • high risk:
      • pacemaker or defibrillator placement (potential for profound neurologic consequences): 3.5% on warfarin therapy, 16% with bridging anticoagulation (2)
      • coronary intervention
      • electrophysiology testing and/or ablation
  • Dental:
    • low risk: tooth extraction, endodontic procedures (root canal)
    • high risk: reconstructive procedures
  • Dermatology:
    • low risk: minor skin procedures (excision of basal and squamous cell cancers, nevi, actinic keratoses, premalignant lesions)
    • high risk: major procedures (wide excision of melanoma)
  • Gastroenterology:
    • low risk:
      • passage of endoscope for diagnostic purposes (including balloon enteroscopy) with or without mucosal biopsy
      • endoscopic retrograde cholangiopancreatography without sphincterotomy
      • endoscopic ultrasound without fine-needle aspiration
      • nonthermal (cold) snare removal of small polyps
      • lumenal self-expanding metal stent placement (controversial)
    • high risk: 
      • large polypectomy (>1 cm)
      • endoscopic mucosal and submucosal dissection
      • biliary or pancreatic sphincterotomy
      • percutaneous endoscopic gastrostomy
      • endoscopic ultrasound with fine-needle aspiration or needle biopsy
      • coagulation or ablation of tumors, vascular lesions
      • percutaneous liver biopsy
      • variceal band ligation (controversial): The risk of delayed bleeding following EVL (2.4 %-5.7 %) and sclerotherapy (4 %-25 %) is high (3,4).
  • General surgery:
    • low risk:
      • suture of superficial wounds
    • high risk:
      • major tissue injury
      • vascular organs (spleen, liver, kidney)
      • bowel resection
      • laparoscopy
  • Gynecologic surgery:
    • low risk:
      • diagnostic colposcopy, hysteroscopy
      • dilation and curettage, endometrial biopsy
      • insertion of intrauterine device
    • high risk:
      • laparoscopic surgery
      • bilateral tube ligation
      • hysterectomy
  • Interventional radiology:
    • low risk:
      • simple catheter exchange in well-formed, nonvascular tracts (e.g., gastrostomy, nephrostomy, cholecystostomy tubes)
      • thoracentesis
      • paracentesis
      • aspiration of abdominal or pelvic abscesses, placement of small-caliber drains
      • peripheral catheter placement, nontunneled catheter (peripherally inserted central catheter) placement
      • inferior vena cava filter placement
      • temporary dialysis catheter placement
    • high risk:
      • percutaneous transhepatic cholangiography or nephrostomy
      • percutaneous drainage of liver abscess or gallbladder
      • chest tube placement
      • aggressive manipulation of drains or dilation of tracts
      • biopsy of organs
      • hickmann and tunneled dialysis catheter placement
  • Intravascular procedures:
    • low risk: venous access
    • high risk:
      • arterial puncture
      • transvenous ablation
  • Neurology:
    • low risk: none
    • high risk:
      • lumbar puncture (potential for profound neurologic consequences)
      • myelography
      • needle electromyography (controversial)
  • Neurosurgery:
    • low risk: none
    • high risk: intracranial, spinal surgery (potential for profound neurologic consequences)
  • Ophthalmology:
    • low risk:
      • cataract surgery
      • intraocular injections
      • (Avoid retrobulbar anesthesia - controversial)
    • high risk:
      • periorbital surgery
      • vitreoretinal surgery
  • Orthopedic surgery:
    • low risk: arthrocentensis
    • high risk:
      • joint replacement
      • arthroscopy
  • Otolaryngologic surgery:
    • low risk:
      • diagnostic fiberoptic laryngoscopy or nasopharyngoscopy, sinus endoscopy
      • fine needle aspiration
      • vocal cord injection
    • high risk:
      • any sinus surgery
      • biopsy or removal of nasal polyps
      • thyroidectomy
      • parotidectomy
      • septoplasty
      • turbinate cautery
  • Plastic surgery:
    • low risk: injection therapy
    • high risk: reconstruction
  • Pulmonary:
    • low risk:
      • diagnostic bronchoscopy with or without bronchioalveolar lavage
      • endobronchial fine-needle aspirate (controversial)
      • airway stent placement (controversial)
    • high risk:
      • tumor ablation (laser)
      • transbronchial biopsy
      • stricture dilation
  • Rheumatology
    • low risk: arthrocentesis
    • high risk: none
  • Urology:
    • low risk:
      • circumcision
      • cystoscopy without biopsy
    • high risk:
      • extracorporeal shock-wave lithotripsy
      • transurethral prostatectomy
      • bladder resection
      • tumor ablation
      • kidney biopsy
  • Vascular surgery:
    • low risk: none
    • high risk:
      • carotid endarterectomy
      • open or endovascular aneurysm repair
      • vascular bypass grafting

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References:
  1. If not otherwise mentionned: Current Concepts: Management of Antithrombotic Therapy in Patients Undergoing Invasive Procedurs. NEJM. 2013;368(22):2113-2124: full text | pdf.
  2. Pacemaker or Defibrillator Surgery without Interruption of Anticoagulation. NEJM. 2013;368(22):2084-2093: full text | pdf.
  3. Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2011;43(5):445-461: full text.
  4. Incidence and management of esophageal stricture formation, ulcer bleeding, perforation, and massive hematoma formation from sclerotherapy versus band ligation. The American Journal of Gastroenterology. 2001.96;437-441: full text | pdf.